Title of article :
TAP Test Image Dynamic Tracking Study after Thyroid Cancer Surgery and after Radiotherapy and Chemotherapy
Author/Authors :
Wang, Changliang Department of Galactophore Surgery - Weifang People’s Hospital - Shandong, China , Gu, Yongxue Department of Galactophore Surgery - Weifang People’s Hospital - Shandong, China , Men, Xiaojuan Department of Galactophore Surgery - Weifang People’s Hospital - Shandong, China , Sun, Peng Weifang Medical University - Shandong, China , Chen, Meili Weifang Brain Hospital Emergency Department - Shandong, China
Abstract :
Thyroid cancer is a relatively common endocrine gland malignant tumor; if improper treatment, there will be a high risk of
recurrence or metastasis, and abnormal sugar chain glycoprotein (TAP) has a close relationship with the development of the
disease; therefore, the purpose of this article is to discuss abnormal sugar chain glycoprotein (TAP) as thyroid cancer curative
effect evaluation and radiation and chemotherapy after surgery clinical significance. In this paper, 95 patients with thyroid
cancer diagnosed in a hospital were selected as the study objects and treated as the observation group. The clinical and followup data of the observation group were retrospectively analyzed. Meanwhile, 55 healthy patients were randomly selected as the
control group. TAP, squamous cell carcinoma antigen (SCC) level, and carcinoembryonic antigen (CEA) level were detected in
peripheral blood of 95 patients with thyroid cancer before and after treatment. The short-term efficacy was evaluated by chest
CT examination, and the changes of the three markers before and after treatment and the correlation with the short-term
efficacy of the patients were compared. According to the results of testing, the TAP positive expression in patients before
radiotherapy can better predict the recent curative effect has certain clinical value; before radiotherapy TAP positive expression
rate was significantly higher than that of healthy people, TAP positive expression quantity decreased obviously after radiation
treatment, and patients with a recent radiotherapy curative effect is good or bad and negatively correlated with the degree of
TAP protein positive expression; TAP high protein in patients with recent poor radiation effects, prompt the factor can be
predicted in the near future curative effect of the molecular markers, and can TAP level for clinicians provide certain reference
for targeted therapy.
Keywords :
Dynamic , TAP , Chemotherapy , CEA
Journal title :
Computational and Mathematical Methods in Medicine