Author/Authors :
Liu, Dingsheng Department of Oncology and Hematology - Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital - Shanghai, China , Zuo, Xiaojia Department of Oncology and Hematology - Shanghai University of Medicine and Health Sciences Affiliated Zhoupu Hospital - Shanghai, China , Zhang, Peng Shanghai University of Medicine and Health Sciences - Shanghai, China , Zhao, Rui Shanghai University of Medicine and Health Sciences - Shanghai, China , Lai, Donglin Shanghai University of Medicine and Health Sciences - Shanghai, China , Chen, Kaijie Shanghai University of Medicine and Health Sciences - Shanghai, China , Han, Yuru Shanghai University of Medicine and Health Sciences - Shanghai, China , Wan, Guoqing Shanghai University of Medicine and Health Sciences - Shanghai, China , Zheng, Yanjun Shanghai University of Medicine and Health Sciences - Shanghai, China , Lu, Changlian Shanghai University of Medicine and Health Sciences - Shanghai, China , Gu, Xuefeng Shanghai University of Medicine and Health Sciences - Shanghai, China
Abstract :
Amyotrophic lateral sclerosis (ALS) is an incurable neurodegenerative disease that primarily affects motor neurons, causing muscle
atrophy, bulbar palsy, and pyramidal tract signs. However, the aetiology and pathogenesis of ALS have not been elucidated to date.
In this study, a competitive endogenous RNA (ceRNA) network was constructed by analyzing the expression profiles of messenger
RNAs (mRNAs) and long noncoding RNAs (lncRNAs) that were matched by 7 ALS samples and 4 control samples, and then a
protein-protein interaction (PPI) network was constructed to identify the genes related to ALS. Gene Ontology (GO) was used
to study the potential functions of differentially expressed mRNAs (DEmRNAs) in the ceRNA network. For the ALS and
control groups, 247177 potential lncRNA-mRNA ceRNA relationship pairs were screened. Analysis of significant relationship
pairs demonstrated that the PPI modules formed by the MALAT1-regulated SYNRG, ITSN2, PICALM, AP3B1, and AAK1 genes
may play important roles in the pathogenesis of ALS, and these results may help to characterize the pathogenesis of ALS.
