Author/Authors :
Gniadek, Thomas J. Division of Clinical Microbiology - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA , Cappel, Mark A. Department of Dermatology - Mayo Clinic, Jacksonville, USA , Wengenack, Nancy L. Division of Clinical Microbiology - Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN 55905, USA , Libertin, Claudia R. Division of Infectious Disease - Department of Medicine, Mayo Clinic, Jacksonville, USA
Abstract :
A female presented in the sixth decade of life with a history of undifferentiated small cell carcinoma of the right breast in clinical remission, status-post chemotherapy and resection 6 years previously, presented with a chronic anterior knee skin nodule that grew in size over the prior 5–6 weeks. She had no history of opportunistic infections or recent immunosuppression. As it grew, the nodule became tender to touch. Examination revealed a 4–6 mm superficial purple-red nodule. Also, a similar lesion was present on the dorsum of her left foot for the past year, which also recently grew and became tender. The patient did report frequently kneeling on soil when gardening in Florida. She reported no other symptoms. Due to a concern for cutaneous metastasis of the patient’s previously diagnosed small cell carcinoma of the breast, the anterior knee lesion was biopsied. Histology revealed histocyte-rich inflammation with foci of acute inflammation as well as pigmented fungal forms. Subsequent fungal culture of excised tissue grew Cladophialophora bantiana, identified by ribosomal gene DNA sequencing.
