• Title of article

    Stem cells from adipose tissue improve the time of wound healing in rats

  • Author/Authors

    Ohashi, Camila Melo Department of Surgery - Universidade Federal do Pará (UFPA), Belem-PA, Brazil , Caldeira, Fabio Alves Morikawa Department of Surgery - Universidade Federal do Pará (UFPA), Belem-PA, Brazil , Feitosa-Junior, Denilson José Silva Department of Integrated Health - Universidade Estadual do Pará (UEPA), Belem-PA, Brazil , Valente, André Lopes Department of Integrated Health - Universidade Estadual do Pará (UEPA), Belem-PA, Brazil , Dutra, Paulo Roberto Witter Department of Biology - UFPA, Belem-PA, Brazil , Miranda, Moysés dos Santos Department of Biological Sciences - UFPA, Belem-PA, Brazil , Santos, Simone do Socorro Damasceno Department of Histology and Embriology - UFPA, Belem-PA, Brazil , Brito, Marcus Vinicius Henriques Department of Integrated Health - UEPA, Belem-PA, Brazil , Ohashi, Otávio Mitio Department of Biological Sciences - UFPA, Belem-PA, Brazil , Yasojima, Edson Yuzur Department of Surgery - UFPA, Belem-PA, Brazil

  • Pages
    5
  • From page
    821
  • To page
    825
  • Abstract
    PURPOSE: To evaluate the Adipose Stem Cells (ACS) therapy efficacy on the time and quality of wound healing process in rats. METHODS: Nine male Wistar rats were randomly distributed into three groups I) 7 days of healing; II) 14 days of healing; III) 21 days of healing. Four incisions were made on the dorsal surface of each rat and then treated with intralesional ACS, meloxicam, and no treatment and ACS+meloxicam. Macroscopic evaluation was measured by percentage of healing and histopathological by hematoxylin-eosin was performed. RESULTS: All groups have the wound reduced during the three weeks (p<0.001) and after 14 days of healing had greater reduction than others. Wounds treated with ASC had accelerated healing in relation to no treatment and only meloxicam (p<0.001), excepting the ASC+Meloxicam that was similar (p=0.13). There was no difference in histopathological analysis between lesions. CONCLUSION: Adipose stem cell have benefits in reducing time of healing of experimental model of wound in rats, observed 7 days of after application.
  • Keywords
    Adipose Tissue , Wound Healing , Stem Cells , Rats
  • Journal title
    Acta Cirurgica Brasileira
  • Serial Year
    2016
  • Full Text URL
    www.scielo.br/j/acb/a/D7qs9YsfcvMP5TcgPkYPHTr/?format=pdf&lang=en
  • Record number

    2616056

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2616056