Author/Authors :
Gvazava, I.G Koltsov Institute of Developmental Biology - Russian Academy of Sciences, Russia , Rogovaya, O.S Koltsov Institute of Developmental Biology - Russian Academy of Sciences, Russia , Borisov, M.A Koltsov Institute of Developmental Biology - Russian Academy of Sciences, Russia , Vorotelyak, E.A Koltsov Institute of Developmental Biology - Russian Academy of Sciences, Russia , Vasiliev, A.V Koltsov Institute of Developmental Biology - Russian Academy of Sciences, Russia
Abstract :
The global prevalence of diabetes mellitus and its severe complications is on the rise. The study of the pathogenesis of the onset and the progression of complications related to the disease, as well as the search for new therapeutic agents and methods of treatment, remains relevant. Experimental models are extremely important in the study of diabetes. This survey contains a synthesis of the most commonly used experimental animal models described in scientific literature. The mechanisms of the streptozotocin model are also analyzed and discussed, as it is considered as the most adequate and easily reproducible diabetes model. A review of the significant advantages and disadvantages of the described models has also been conducted.
Keywords :
streptozotocin , pathogen-esis , Langerhans islets , hyperglycemia , experimental laboratory animals , diabetes , beta-cells
