Author/Authors :
Guller, A.E. Macquarie University, russia , Grebenyuk, P.N. no affiliation , Shekhter, A.B. Sechenov First Moscow State Medical University, russia , Zvyagin, A.V. Macquarie University, russia , Deyev, S.M Macquarie University, russia
Abstract :
This review focuses on modeling of cancer tumors using tissue engineering technology. Tumor tissue engineering (TTE) is a new method of three-dimensional (3D) simulation of malignant neoplasms. Design and development of complex tissue engineering constructs (TECs) that include cancer cells, cell-bearing scaffolds acting as the extracellular matrix, and other components of the tumor microenvironment is at the core of this approach. Although TECs can be transplanted into laboratory animals, the specific aim of TTE is the most real-istic reproduction and long-term maintenance of the simulated tumor properties in vitro for cancer biology re-search and for the development of new methods of diagnosis and treatment of malignant neoplasms. Successful implementation of this challenging idea depends on bioreactor technology, which will enable optimization of culture conditions and control of tumor TECs development. In this review, we analyze the most popular biore-actor types in TTE and the emerging applications.
Keywords :
bioreactors , cancer , models , tissue engineering
