Author/Authors :
Franco, Rocco Department of Biomedicine and Prevention - Section of Clinical Nutrition and Nutrigenomic - School of Applied Medical-Surgical Sciences - University of Rome Tor Vergata, Rome, Italy , Miranda, Michele Department of Systems Medicine - Medical School - University of Rome Tor Vergata, Rome, Italy , Di Renzo, Laura Department of Biomedicine and Prevention - Section of Clinical Nutrition and Nutrigenomic - School of Applied Medical-Surgical Sciences - University of Rome Tor Vergata, Rome, Italy , De Lorenzo, Antonino Department of Biomedicine and Prevention - Section of Clinical Nutrition and Nutrigenomic - School of Applied Medical-Surgical Sciences - University of Rome Tor Vergata, Rome, Italy , Barlattani, Alberta Department of Clinical Sciences and Translational Medicine -University of Rome Tor Vergata, Rome, Italy , Bollero, Patrizio Department of Systems Medicine - Medical School - University of Rome Tor Vergata, Rome, Italy
Abstract :
Glanzmann’s thrombastenia (GT) is the most frequent inherited condition. GT is a genetic autosomal recessive disease caused by
the alteration of the genes ITGA2B and ITGB3, located on the chromosome 17. The incidence of GT is calculated in 1 on 1000000.
The patients, during their life, show episodes of mucocutaneous bleeding, epistaxis, and gingival bleeding. Some subjects
required continuous bleeding transfusion. The aim of this case report is to demonstrate that oral assumption of tranexamic
acid is a gold standard to prevent excessive bleeding. The patient GM of 36 years old with GT type 1 needs dental extractions of
the teeth 4.7 and 4.8 at the “Tor Vergata” University Hospital in Rome. The specialist suggests that 3 days before surgery, the
patient must take 6 vials every day of tranexamic acid that is used in obstetrics and gynecology. The teeth were extracted and
applied suture. The patient is observed and is recommended mouth rinse with tranexamic acid. No bleeding complications
were observed.
