Author/Authors :
Minakov, A.N Branch of Shemyakin and Ovchinnikov institute of bioorganic chemistry Russian academy of sciences, Pushchino, Russia , Chernov, A.S Branch of Shemyakin and Ovchinnikov institute of bioorganic chemistry Russian academy of sciences, Pushchino, Russia , Asutin, D.S Federal State Autonomous Institution «N .N. Burdenko National Scientific and Practical Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia , Konovalov, N.A Federal State Autonomous Institution «N .N. Burdenko National Scientific and Practical Center for Neurosurgery» of the Ministry of Healthcare of the Russian Federation, Moscow, Russia , Telegin, G.B Branch of Shemyakin and Ovchinnikov institute of bioorganic chemistry Russian academy of sciences, Pushchino, Russia
Abstract :
Pathologies associated with spinal cord injury are some of the leading diseases in the world. The search for new therapeutic agents and 3D biodegradable materials for the recovery of spinal cord functions is a topical issue. In this review, we have summarized the literature data on the most common experimental models of spinal cord injury in laboratory rats and analyzed the experience of using 3D biodegradable materials (scaf-folds) in experimental studies of spinal trauma. The advantages and disadvantages of the described models are systematically analyzed in this review.
Keywords :
scaffolds , biomodeling , laboratory rat , spinal cord injury
