Author/Authors :
Kulikova, V.V Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russia , Chernukha, M.Yu N.F.Gamaleya National Research Centre of Epidemiology and Microbiology - Ministry of Health of Russian Federation, Moscow, Russia , Morozova, E.A Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russia , Revtovich, S. V Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russia , Rodionov, A.N Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russia , Koval, V.S Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russia , Avetisyan, L.R N.F.Gamaleya National Research Centre of Epidemiology and Microbiology - Ministry of Health of Russian Federation, Moscow, Russia , Kuliastova, D.G N.F.Gamaleya National Research Centre of Epidemiology and Microbiology - Ministry of Health of Russian Federation, Moscow, Russia , Shaginyan, I.A N.F.Gamaleya National Research Centre of Epidemiology and Microbiology - Ministry of Health of Russian Federation, Moscow, Russia , Demidkina, T.V Engelhardt Institute of Molecular Biology of the Russian Academy of Sciences, Moscow, Russia
Abstract :
The multiresistance of A. ruhlandii 155B, B. cenocepacia 122, and P. aeruginosa 48B strains isolated from patients with cystic fibrosis was established. The antibacterial effect of allicin, dimethyl thiosulfinate, and dipropyl thiosulfinate on multidrug-resistant strains was shown. Thiosulfinates can have both bacteriostatic and bactericidal effects depending on the microorganism and the concentration. The studied thiosulfinates may be candidates for the development of alternative antibiotic drugs to treat infections caused by multidrug-resistant pathogens.
Keywords :
thiosulfinates , methionine γ-lyase , cystic fibrosis , antibacterial activity , allicin
