Author/Authors :
Stanishneva-Konovalova, T.B. Lomonosov Moscow State University, russia , Derkacheva, N.I A.I. Evdokimov Moscow State University of Medicine and Dentistry, russia , Polevova, S.V. Lomonosov Moscow State University, russia , Sokolova, O.S. Lomonosov Moscow State University, russia
Abstract :
Many cellular processes are associated with membrane remodeling. The BAR domain protein family plays a key role in the formation and detection of local membrane curvatures and in attracting other proteins, including the regulators of actin dynamics. Based on their structural and phylogenetic properties, BAR domains are divided into several groups which affect membrane in various ways and perform different functions in cells. However, recent studies have uncovered evidence of functional differences even within the same group. This review discusses the principles underlying the interactions of different groups of BAR domains, and their indi-vidual representatives ,with membranes.
