Title of article
Flavoprotein miniSOG Cytotoxisity Can Be Induced By Bioluminescence Resonance Energy Transfer
Author/Authors
Shramova, E.I. Shemyakin/Ovchinnikov Institute of Bioorganic Chemistry - Russian Academy of Sciences, russia , Proshkina, G.M. Shemyakin/Ovchinnikov Institute of Bioorganic Chemistry - Russian Academy of Sciences, russia , Chumakov, S.P. Shemyakin/Ovchinnikov Institute of Bioorganic Chemistry - Russian Academy of Sciences, russia , Khodarovich, Y.M. Shemyakin/Ovchinnikov Institute of Bioorganic Chemistry - Russian Academy of Sciences, russia , Deyev, S.M. Shemyakin/Ovchinnikov Institute of Bioorganic Chemistry - Russian Academy of Sciences, russia
Pages
6
From page
118
To page
123
Abstract
In this study, we investigated the possibility of phototoxic flavoprotein miniSOG (photosensitizer) excitation in cancer cells by bioluminescence occurring when luciferase NanoLuc oxidizes its substrate, fu-rimazine. We have shown that the phototoxic flavoprotein miniSOG expressed in eukaryotic cells in fusion with NanoLuc luciferase is activated in the presence of its substrate, furimazine. Upon such condition, miniSOG possesses photoinduced cytotoxicity and causes a 48% cell death level in a stably transfected cell line.
Farsi abstract
فاقد چكيده فارسي
Keywords
bioluminescence resonance energy transfer , NanoLuc luciferase , flavoprotein miniSOG , photody-namic therapy
Journal title
Acta Naturae
Serial Year
2016
Full Text URL
Record number
2616300
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