Author/Authors :
Kulemzin, S.V. Institute of Molecular and Cellular Biology, russia , Kuznetsova, V.V. Institute of Molecular and Cellular Biology, russia , Mamonkin, M. Baylor College of Medicine, russia , Taranin, A.V. Institute of Molecular and Cellular Biology, russia , Gorchakov, А.A. Institute of Molecular and Cellular Biology, russia
Abstract :
Chimeric antigen receptors (CARs) are recombinant protein molecules that redirect cytotoxic lym-phocytes toward malignant and other target cells. The high feasibility of manufacturing CAR-modified lym-phocytes for the therapy of cancer has spurred the development and optimization of new CAR T cells directed against a broad range of target antigens. In this review, we describe the main structural and functional elements constituting a CAR, discuss the roles of these elements in modulating the anti-tumor activity of CAR T cells, and highlight alternative approaches to CAR engineering.
Keywords :
adoptive immunotherapy , cancer , chimeric antigen receptor , T cells
