Author/Authors :
Göktuğ Ertem, Ahmet Department of Cardiology - Turkish High Specialty Training and Research Hospital - Ankara - Turkey , Ünal, Sefa Department of Cardiology - Turkish High Specialty Training and Research Hospital - Ankara - Turkey , Han Efe, Tolga Department of Cardiology - Dışkapı Yıldırım Beyazıt Training and Research Hospital - Ankara - Turkey , Açar, Burak Department of Cardiology - Turkish High Specialty Training and Research Hospital - Ankara - Turkey , Yayla, Çağrı Department of Cardiology - Turkish High Specialty Training and Research Hospital - Ankara - Turkey , Serdar Kuyumcu, Mevlüt Department of Cardiology - Turkish High Specialty Training and Research Hospital - Ankara - Turkey , Kırbaş, Özgür Department of Cardiology - Turkish High Specialty Training and Research Hospital - Ankara - Turkey , Köseoğlu, Cemal Department of Cardiology - Tokat State Hospital - Tokat - Turkey , Kadri Akboğa, Mehmet Department of Cardiology - Turkish High Specialty Training and Research Hospital - Ankara - Turkey , Gayretli Yayla, Kadriye Department of Cardiology - Dışkapı Yıldırım Beyazıt Training and Research Hospital - Ankara - Turkey , Gökaslan, Serkan Department of Cardiology - Turkish High Specialty Training and Research Hospital - Ankara - Turkey , Aydoğdu, Sinan Department of Cardiology - Turkish High Specialty Training and Research Hospital - Ankara - Turkey
Abstract :
Objective: Previous studies revealed the relationship between stable coronary artery disease (CAD) and serum adropin level, but this relation- ship has not been investigated in patients with non-ST segment elevation myocardial infarction (NSTEMI). The present study is an analysis of the relationship between adropin and severity of CAD assessed based on SYNTAX score in patients with NSTEMI.
Methods: A total of 109 participants, 80 patients with NSTEMI and 29 healthy individuals, were prospectively enrolled in the study. Patients with NSTEMI were divided to 2 groups: high SYNTAX score (≥32) (35 patients) and low SYNTAX score (<32) (45 patients). Adropin level was measured from blood serum samples using enzyme-linked immunosorbent assay test.
Results: Patients with NSTEMI and high SYNTAX score had significantly lower serum adropin level (2357.30 pg/mL±821.58) compared to NSTEMI patients with low SYNTAX score (3077.00 pg/mL±912.86) and control group (3688.00±956.65). Adropin cut-off value for predicting high SYNTAX score on receiver-operating characteristic curve analysis was determined to be 2759 pg/mL, with a sensitivity of 63% and a specificity of 57%. Adropin was an independent predictor for high SYNTAX score (odds ratio=0.999; 95% confidence interval: 0.998–1.000; p=0.007).
Conclusion: Adropin could be an alternative blood sample value for predicting severity of CAD. (Anatol J Cardiol 2017; 17: 119-24)
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