Title of article
Antiretroviral Activity Of a Novel Pyrimidyl-Di(Diazaspiroalkane) Derivative
Author/Authors
Novoselova , E.A. Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences, russia , Riabova, O.B. Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences, russia , Leneva, I.A. Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences, russia , Nesterenko, V.G. Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences, russia , Bolgarin, R.N. Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences, russia , Makarov, V.A. Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences, russia
Pages
3
From page
105
To page
107
Abstract
A novel compound, 3,3’-(5-nitropyrimidine-4,6-diyl)bis-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hex-adecane tetrachloride dihydrochloride, was synthesized. The compound was found to inhibit the replication of various viral families by blocking specific heparan sulfate receptors on the host cell’s surface. In experiments, the compound was found to be highly effective against several strains of HIV retroviruses
Farsi abstract
فاقد چكيده فارسي
Keywords
antiviral activity , dispiro compounds , heparan sulfate , HIV
Journal title
Acta Naturae
Serial Year
2017
Full Text URL
Record number
2616408
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