Author/Authors :
Novoselova , E.A. Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences, russia , Riabova, O.B. Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences, russia , Leneva, I.A. Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences, russia , Nesterenko, V.G. Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences, russia , Bolgarin, R.N. Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences, russia , Makarov, V.A. Federal Research Centre «Fundamentals of Biotechnology» of the Russian Academy of Sciences, russia
Abstract :
A novel compound, 3,3’-(5-nitropyrimidine-4,6-diyl)bis-3,12-diaza-6,9-diazoniadispiro[5.2.5.2]hex-adecane tetrachloride dihydrochloride, was synthesized. The compound was found to inhibit the replication of various viral families by blocking specific heparan sulfate receptors on the host cell’s surface. In experiments, the compound was found to be highly effective against several strains of HIV retroviruses
Keywords :
antiviral activity , dispiro compounds , heparan sulfate , HIV
