Author/Authors :
Azevedo, Ítalo Medeiros Universidade Federal do Rio Grande do Norte (UFRN), NatalRN, Brazil , Carvalho, Marília Daniela Ferreira Universidade Federal do Rio Grande do Norte (UFRN), NatalRN, Brazil , Nascimento, Rafael Pereira Universidade Federal do Rio Grande do Norte (UFRN), NatalRN, Brazil , Macedo, Robson Radiology Institute of Natal, Brazil , Aquino, Mônica Raquel de Souza Universidade Federal do Rio Grande do Norte (UFRN), NatalRN, Brazil , Medeiros, Aldo Cunha Universidade Federal do Rio Grande do Norte (UFRN), NatalRN, Brazil
Abstract :
Purpose:
To examine a correlation of micro-PET images with photographic images of the digestive organs in abdominal sepsis model.
Methods:
Male Wistar rats weighing 265±18g were used. Abdominal sepsis was induced by ligature and cecal puncture. Micro-PET Images from abdominal cavity septic foci were obtained using 18-Fluoro-deoxyglucose, looking for a correlation with photographic images of abdominal cavity organs. Pearson's correlation test was used.
Results:
The mean standard uptake values (SUV) and lesion areas were 2.58±0.63SUVbwg/ml and 546.87±300.95mm2, respectively. There was a strong positive correlation between the two variables (r=0.863, p=0.137), which resulted in a coefficient of determination r2?0.75, meaning that 75% of SUV variation is explained by the lesion areas of digestive organs.
Conclusion:
Micro-PET allows high throughput assessment of lesion count and volume in pre-clinical rat model of CPL abdominal sepsis.
Keywords :
Sepsis , Fluorodeoxyglucose F18 , Positron-Emission Tomography , Rats
