Author/Authors :
Barros, Pedro Paulo Faculty of Pharmaceutical Sciences - Pontifícia Universidade Católica de Campinas (PUC-Campinas), Brazil , Gonçalves, Gisele Mara Silva Faculty of Pharmaceutical Sciences - PUC-Campinas, Brazil , Silva, Gustavo Henrique da Faculty of Pharmaceutical Sciences - PUC-Campinas, Brazil , Bastos, Maria Clara Villaça Dias School of Medicine - FAPIC - PUC-Campinas, Brazil , Ramos, Loren Nogaroto School of Medicine - FAPIC - PUC-Campinas, Brazil , Fernandes, Marilia Marinello School of Medicine - FAPIC - PUC-Campinas, Brazil
Abstract :
Purpose:
To investigate the effects of lycopene and resveratrol pretreatment on hepatic hyperplasia in partially hepatectomized rats.
Methods:
The lycopene group and the resveratrol group received 40 mg/kg/day of lycopene or resveratrol, respectively (dissolved in olive oil or in saline solution, respectively) and administered via a gastric tube for 30 days. The partially hepatectomzed (PH) control groups received saline or olive oil via a gastric tube for 30 days, respectively, and the normal control group received no treatment. Liver tissue and intracardiac blood samples were obtained 24, 36 or 48 h after PH.
Results:
No areas of fibrosis were detected. No significant changes in mitotic index, in the number of apoptosis events or in aspartate aminotransferase and alanine aminotransferase levels were observed.
Conclusions:
Lycopene and resveratrol pretreatment did not interfere on hepatic hyperplasia in partially hepatectomized rats.
Keywords :
Alanine Transaminase , Aspartate Aminotransferases , Apoptosis , Mitotic Index , Rats
