• Title of article

    Influence of remote ischemic conditioning and tramadol hydrochloride on oxidative stress in kidney ischemia/reperfusion injury in rats

  • Author/Authors

    Oliveira, Rita de Cássia Silva de Department of Pharmacology - Universidade Estadual do Pará (UEPA), Belem-PA, Brazil , Brito, Marcus Vinicius Henriques Department of Experimental Surgery - UEPA, Belem-PA, Brazil , Ribeiro, Rubens Fernando Gonçalves UEPA, Belem-PA, Brazil , Oliveira, Leonam Oliver Durval UEPA, Belem-PA, Brazil , Monteiro, Andrew Moraes School of Medicine - UEPA, Belem-PA, Brazil , Brandão, Fernando Mateus Viegas School of Medicine - UEPA, Belem-PA, Brazil , Cavalcante, Lainy Carollyne da Costa School of Medicine - Centro Universitário do Pará (CESUPA), Belem-PA, Brazil , Gouveia, Eduardo Henrique Herbster School of Medicine - Centro Universitário do Pará (CESUPA), Belem-PA, Brazil , Henriques, Higor Yuri Bezerra School of Medicine - Centro Universitário do Pará (CESUPA), Belem-PA, Brazil

  • Pages
    7
  • From page
    229
  • To page
    235
  • Abstract
    Purpose: To evaluate the effects of tramadol hydrochloride associated to remote ischemic perconditioning on oxidative stress. Methods: Twenty five male rats (Wistar) underwent right nephrectomy and were distributed into five groups: Sham group (S); Ischemia/Reperfusion group (I/R) with 30 minutes of renal ischemia; Remote ischemic perconditioning group (Per) with three cycles of 10 minutes of I/R performed during kidney ischemia; Tramadol group (T) treated with tramadol hydrochloride (40mg/kg); remote ischemic perconditioning + Tramadol group (Per+T) with both treatments. Oxidative stress was assessed after 24 hours of reperfusion. Results: Statistical differences were observed in MDA levels between I/R group with all groups (p<0.01), in addition there was difference between Tramadol with Sham, Per and Per+T groups (p<0.05), both in plasma and renal tissue. Conclusion: Remote ischemic perconditioning was more effective reducing renal ischemia-reperfusion injury than administration of tramadol or association of both treatments.
  • Keywords
    Tramadol , Ischemia , Reperfusion , Oxidative Stress , Kidney , Rats
  • Journal title
    Acta Cirurgica Brasileira
  • Serial Year
    2017
  • Full Text URL
    www.scielo.br/j/acb/a/P7yhtbvSGCC3zTWY6T5wxgx/?lang=en&format=pdf
  • Record number

    2616602

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2616602