Author/Authors :
Shepherd, S. J. West of Scotland Specialist Virology Centre - Level 5 New Lister Building, Glasgow Royal Infirmary, 10-16 Alexandra Parade, G31 2ER, UK , Sykes, C. Infectious Diseases Unit - The Brownlee Centre - Gartnavel General Hospital, Glasgow G12 0YN, UK , Jackson, C. West of Scotland Specialist Virology Centre - Level 5 New Lister Building, Glasgow Royal Infirmary, 10-16 Alexandra Parade, G31 2ER, UK , Bell, D. J. Infectious Diseases Unit - The Brownlee Centre - Gartnavel General Hospital, Glasgow G12 0YN, UK , Gunson, R. N. West of Scotland Specialist Virology Centre - Level 5 New Lister Building, Glasgow Royal Infirmary, 10-16 Alexandra Parade, G31 2ER, UK
Abstract :
HIV-1 infects an estimated 37 million people worldwide, while the rarer HIV-2 infects 1–2 million worldwide. HIV-2 is mainly restricted to West African countries. The majority of patients in Scotland are diagnosed with HIV-1, but in 2013 the West of Scotland Specialist Virology Centre (WoSSVC) diagnosed Scotland’s first HIV-2 positive case in a patient from Côte d’Ivoire. HIV-2 differs from HIV-1 in terms of structural viral proteins, viral transmissibility, prolonged period of latency, intrinsic resistance to certain antivirals and how to monitor the effectiveness of treatment. Over the course of 5 years the patient has required several changes in treatment due to both side effects and pill burden. This case highlights the complexity of HIV-2 patient management over time.
Keywords :
HIV2 , antiretrovirals , diagnosis , treatment
