Author/Authors :
Youssefi, Masoud Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Ghazvini, Kiarash Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences, Mashhad, Iran , Casseb, Jorge Department of Dermatology - Institute of Tropical Medicine of São Paulo/ Laboratory of Dermatology and Immunodeficiencies - University of São Paulo Medical School, São Paulo, Brazil , keikha, Masoud Antimicrobial Resistance Research Center - Mashhad University of Medical Sciences, Mashhad, Iran
Abstract :
We have little information about the definite role of the thioredoxin antioxidant complex system during viral infection, particularly during human T-cell lymphotropic virus type 1 (HTLV-1) infection and the HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) state. Therefore, we conducted comprehensive next-generation sequencing (NGS) analysis to determine Trx system expression changes in three categories of subjects: sero-negative HTLV-1 individuals, asymptomatic HTLV-1 people and HAM/TSP patients. We found that Trx capacity is reduced in the HAM/TSP state compared to healthy individuals, which indicates increasing inflammation and reduction of apoptosis, which might contribute to the progression of inflammation in the spinal cord, which in turn may develop into the HAM/TSP state.
Keywords :
HTLV-1 , HAM/TSP , infection , thioredoxin reductase
