Author/Authors :
Mancini, Stefano Department of Internal Medicine and Rehabilitation - Santa Maria Bianca Hospital, AUSL Modena, Mirandola, Modena, Italy , Alboni, Silvia Department of Life Sciences - University of Modena and Reggio Emilia, Modena, Italy , Mattei, Giorgio Association for Research in Psychiatry - Castelnuovo Rangone, Modena, Italy , Rioli, Giulia Department of Biomedical Metabolic and Neural Sciences - University of Modena and Reggio Emilia, Modena, Italy , Sena, Paola Department of Biomedical Metabolic and Neural Sciences - University of Modena and Reggio Emilia, Modena, Italy , Marchi, Mattia Department of Biomedical Metabolic and Neural Sciences - University of Modena and Reggio Emilia, Modena, Italy , Sacchetti, Andrea Department of Biomedical Metabolic and Neural Sciences - University of Modena and Reggio Emilia, Modena, Italy , Boarino, Valentina Gastrointestinal Endoscopy Unit - University of Modena and Reggio Emilia, Modena, Italy , Roncucci, Luca Department of Medical and Surgical Sciences - University of Modena and Reggio Emilia, Modena, Italy , Maria Galeazzi, Gian Department of Biomedical Metabolic and Neural Sciences - University of Modena and Reggio Emilia, Modena, Italy , Ferrari, Silvia Department of Biomedical Metabolic and Neural Sciences - University of Modena and Reggio Emilia, Modena, Italy
Abstract :
Background and aim of the work:Colorectal mucosal precancerous lesions, metabolic syndrome (MetS) and psychiatric disorders may share a common low-grade local and systemic inflammation. Aim is to report on preliminary data concerning a research adopting a psycho-neuro-endocrine-immune (PNEI) approach to study outpatients undergoing colonoscopy. Methods: A sample of patients undergoing colonosco-py was cross-sectionally investigated. Data on colorectal adenomas, MetS, early atherosclerosis, anxious-de-pressive symptoms, personality traits, and inflammatory markers were statistically analyzed. Results: Sixty-two patients were recruited (female 50%, mean age: 60.8±9.4 years). The prevalence of adenomas and MetS was respectively of 45.2% and 41.9%. Anxiety and depressive symptoms were detected in 16 (32.7%) and 9 (18.4%) subjects, respectively. The presence of adenomas positively correlated with male sex (p=0.01), age (p<0.01), IL-6 (p=0.03), hsCRP (p=0.04), and MetS (p=0.03); it was also associated with hsCRP concentra-tion (aOR=3.81, p=0.03). Conclusions: Proinflammatory atherogenic status, psychological traits, increased mu-cosal inflammation, and metabolic parameters may share a common a pathogenic mechanism, worth studying.
Keywords :
colorectal adenoma , metabolic syndrome , psycho-neuro-immuno-endocrinological approach , anxiety , depression
