Author/Authors :
Zubova, S.V Institute of Basic Biological Problems of RAS - FRC PSCBR RAS, Moscow, Russia , Vorovich, M.F FGBNU Federal Scientific Center of Research and Development of Immunobiological Preparations named M.P. Chumakov of RAS - pos. Institute of Poliomyelitis - Kievskoye Highway, Moscow Region, Russia , Gambaryan, A.S FGBNU Federal Scientific Center of Research and Development of Immunobiological Preparations named M.P. Chumakov of RAS - pos. Institute of Poliomyelitis - Kievskoye Highway, Moscow Region, Russia , shmukhametov, A.A FGBNU Federal Scientific Center of Research and Development of Immunobiological Preparations named M.P. Chumakov of RAS - pos. Institute of Poliomyelitis - Kievskoye Highway, Moscow Region, Russia , Grachev, S.V Institute of Basic Biological Problems of RAS - FRC PSCBR RAS, Moscow, Russia , Prokhorenko, I.R Institute of Basic Biological Problems of RAS - FRC PSCBR RAS, Moscow, Russia
Abstract :
The development of a specific inflammation in mice that had been infected by two influenza virus strains, A/chicken/Kurgan/5/2005 (H5N1) and A/Hamburg/2009 MA (H1N1), was studied. We investigated the effect of a non-toxic lipopolysaccharide from Rhodobacter capsulatus PG on the survival and body weight of the mice, production of IgG antibodies, and the induction of pro- and anti-inflammatory cytokines in blood se-rum. The administration of the R. capsulatus PG lipopolysaccharide was shown to induce interferon-β synthesis, both in healthy and influenza A virus-infected mice, and to promote production of antiviral antibodies in the blood of the influenza-infected animals.
Keywords :
cytokines , antiviral anti-bodies , mice , Rhodobacter capsulatus PG lipopolysaccharide , H1N1 , H5N1 , influenza virus
