• Title of article

    The Role of Tumor-Derived Vesicles in the Regulation of Antitumor Immunity

  • Author/Authors

    Ukrainskaya, V.M M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia , Rubtsov, Y.P M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia , Knorre, V.D M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia , Maschan, M.A M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia , Gabibov, A.G M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia , Stepanov, A.V M.M. Shemyakin and Yu.A. Ovchinnikov Institute of Bioorganic Chemistry of the Russian Academy of Sciences, Moscow, Russia

  • Pages
    9
  • From page
    33
  • To page
    41
  • Abstract
    REVIEWS VOL. 11 No 4 (43) 2019 | ACTA NATURAE | 33 ABSTRACT In this article, we present a comprehensive, updated, and elucidative review of the current knowl-edge on the function played by tumor-derived vesicles (TDVs) in the crosstalk between tumor and immune cells. Characterization of the structure, biogenesis, and the major functions of TDVs is reported. The review focuses on particular ways of suppression or activation of CD4+/CD8+ Т cells by tumor-derived vesicles. Tumor-derived vesicles play an important role in the suppression of antitumor immunity. During the last 15 years, vesicle research has elucidated and improved our knowledge about the role of the vesicles in intercellular communication. Nevertheless, there are still blinds spots concerning vesicle heterogeneity and isolation methods, their uptake by target cells, and the role of mRNA in T-cell transformation or suppression. Along with the substantial progress in understanding of the role of tumor-derived vesicles in intercellular communication, novel antitumor therapy strategies based on vesicle inhibition in a tumor microenvironment are likely to appear very soon.
  • Keywords
    tumor microenvironment , CD4+/CD8+ Т cells , immune response , exosomes , vesicles
  • Journal title
    Acta Naturae
  • Serial Year
    2019
  • Full Text URL
    www.ncbi.nlm.nih.gov/pmc/articles/PMC6977957/pdf/AN20758251-11-04-033.pdf
  • Record number

    2617103

    • Link To Document
    https://search.isc.ac/dl/search/defaultta.aspx?DTC=10&DC=2617103