Author/Authors :
Balmasova, I.P A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation, Moscow, Russia , Lomakin, Y.A Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia , Babaev, E.A A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation, Moscow, Russia , Tsarev, V.N A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation, Moscow, Russia , Gabibov, A.G Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia , Smirnov, I.V Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia , Knorre, V.D Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia , Ovchinnikova, L.A Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia , Gnuchev, N.V Engelhardt Institute of Molecular Biology, RAS, Moscow, Russia , Khurs, E.N Engelhardt Institute of Molecular Biology, RAS, Moscow, Russia , Deev, M.S Peoples’ Friendship University of Russia, Moscow, Russia , Kostin, N.N Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Moscow, Russia , Arutyunov, S.D A.I. Evdokimov Moscow State University of Medicine and Dentistry of the Ministry of Healthcare of the Russian Federation, Moscow, Russia
Abstract :
Periodontal diseases, especially those with polymicrobial etiology, are often associated with type 2
diabetes mellitus, proceeding more severely and affecting the course of diabetes mellitus. Recently, this feature
has been associated with the ability of periodontopathogen microflora to cause not only a local infectious process
in the oral cavity, but also to interact with the human immune system and induce various systemic effects. We
investigated changes in the salivary cytokine profile of patients with chronic periodontitis, associated and not
associated with type 2 diabetes mellitus. We observed a statistically significant decrease of MCP-1/CCL2, GM-
CSF, IL-5, IL-6, and IFN-γ in the saliva of patients with chronic periodontitis associated with type 2 diabetes
mellitus in comparison with patients with chronic periodontitis only. All of these cytokines are associated with
macrophage activation. These data are an important contribution to the elucidation of the mechanism of perio-
dontopathogens involvement in the manifestation of the systemic effects of type 2 diabetes.
Keywords :
salivary cytokine profile , periodontal pathogens , IL , bioplex , chemokines , interleukins , type 2 diabetes mellitus , chronic periodontitis
