Author/Authors :
Mammucari, Massimo Primary Care Unit ASL RM 1 - Rome - Italy , Maggiori, Enrica Primary Care Unit ASL RM 1 - Rome - Italy , Russo, Domenico “San Marco” Hospice and Palliative Care - Latina - Italy , Giorgio, Chiara Rehabilitation Unit - F Pirinei Hospital - Altamura - BA - Italy , Ronconi, Gianpaolo Physical Medicine and Rehabilitation Unit - IRCCS - Catholic University of Sacred Heart - Rome - Italy , E Ferrara, Paola Physical Medicine and Rehabilitation Unit - IRCCS - Catholic University of Sacred Heart - Rome - Italy , Canzona, Flora Istituto Dermopatico Dell’Immacolata - IRCCS Foundation - Rome - Italy , Antonaci, Luciano Primary Care Unit ASL RM 1 - Rome - Italy , Violo, Bartolomeo Pain - therapy Unit - S. Spirito Hospital - Rome - Italy , Vellucci, Renato Palliative Care and Pain - therapy Unit – Anesthesiology and Resuscitation Department of Careggi University Hospital - Florence - Italy , Rocco Mediati, Domenico Palliative Care and Pain - therapy Unit – Anesthesiology and Resuscitation Department of Careggi University Hospital - Florence - Italy , Migliore, Alberto Unit of Rheumatology - San Pietro Fatebenefratelli Hospital - Rome - Italy , Massafra, Umberto Unit of Rheumatology - San Pietro Fatebenefratelli Hospital - Rome - Italy , Bifarini, Barbara Section of Anesthesia - Intensive Care - and Pain Medicine - Azienda Ospedaliera - Universitaria Santa Maria Della Misericordia - Perugia - Italy , Gori, Fabio Section of Anesthesia - Intensive Care - and Pain Medicine - Azienda Ospedaliera - Universitaria Santa Maria Della Misericordia - Perugia - Italy , di Carlo, Massimo Pain - therapy Unit - S Pertini Hospital - Rome - Italy , Brauneis, Stefano Pain Center “Enzo Borzomati” - University Hospital of Rome “Policlinico Umberto I” - Rome - Italy , Paolucci, Teresa University G. D’Annunzio Chieti - Department of Medical and Oral Sciences and Biotechnologies - Chieti-Pescara - Italy , Rocchi, Piergiovanni Member of the Italian Society of Mesotherapy - Rome - Italy , Cuguttu, Anna Member of the Italian Society of Mesotherapy - Rome - Italy , Di Marzo, Raffaele Member of the Italian Society of Mesotherapy - Rome - Italy , Bomprezzi, Alessandro Member of the Italian Society of Mesotherapy - Rome - Italy , Santini, Stefania Member of the Italian Society of Mesotherapy - Rome - Italy , Giardini, Manuela Member of the Italian Society of Mesotherapy - Rome - Italy , Rosa Catizzone, Anna Member of the Italian Society of Mesotherapy - Rome - Italy , Troili, Fiammetta Member of the Italian Society of Mesotherapy - Rome - Italy , Dorato, Dario Member of the Italian Society of Mesotherapy - Rome - Italy , Gallo, Alessandra Member of the Italian Society of Mesotherapy - Rome - Italy , Guglielmo, Costanza Member of the Italian Society of Mesotherapy - Rome - Italy , Natoli, Silvia Department of Clinical Science and Translational Medicine - Tor Vergata University - Rome - Italy
Abstract :
Intradermal therapy, known as mesotherapy, is a technique used to inject a drug into the surface layer of the skin. In particular, it involves the use of a short needle to deposit the drug in the dermis. The intradermal microdeposit modulates the drug's kinetics, slowing absorption and prolonging the local mechanism of action. It is successfully applied in the treatment of some forms of localized pain syndromes and other local clinical conditions. It could be suggested when a systemic drug-sparing effect is useful, when other therapies have failed (or cannot be used), and when it can synergize with other pharmacological or nonpharmacological therapies. Despite the lack of randomized clinical trials in some fields of application, a general consensus is also reached in nonpharmacological mechanism of action, the technique execution modalities, the scientific rationale to apply it in some indications, and the usefulness of the informed consent. The Italian Mesotherapy Society proposes this position paper to apply intradermal therapy based on scientific evidence and no longer on personal bias.
