Author/Authors :
Deng, Shengming Department of Nuclear Medicine - The First Affiliated Hospital of Soochow University - Suzhou, China , Wu, Zhifang Department of Nuclear Medicine - First Hospital of Shanxi Medical University - Taiyuan, China , Wu, Yiwei Department of Nuclear Medicine - The First Affiliated Hospital of Soochow University - Suzhou, China , Zhang, Wei Department of Nuclear Medicine - The First Affiliated Hospital of Soochow University - Suzhou, China , Li, Jihui Department of Nuclear Medicine - The First Affiliated Hospital of Soochow University - Suzhou, China , Dai, Na Department of Nuclear Medicine - The First Affiliated Hospital of Soochow University - Suzhou, China , Zhang, Bin Department of Nuclear Medicine - The First Affiliated Hospital of Soochow University - Suzhou, China , Yan, Jianhua Department of Nuclear Medicine - First Hospital of Shanxi Medical University - Taiyuan, China
Abstract :
The objective of this meta-analysis is to explore the correlation between the apparent diffusion coefficient (ADC) on diffusionweighted MR and the standard uptake value (SUV) of 18F-FDG on PET/CT in patients with cancer. Databases such as PubMed
(MEDLINE included), EMBASE, and Cochrane Database of Systematic Review were searched for relevant original articles that
explored the correlation between SUV and ADC in English. After applying Fisher’s 𝑟-to-𝑧 transformation, correlation coefficient (𝑟)
values were extracted from each study and 95% confidence intervals (CIs) were calculated. Sensitivity and subgroup analyses based
on tumor type were performed to investigate the potential heterogeneity. Forty-nine studies were eligible for the meta-analysis,
comprising 1927 patients. Pooled 𝑟 for all studies was −0.35 (95% CI: −0.42–0.28) and exhibited a notable heterogeneity (𝐼
2 =
78.4%; 𝑃 < 0.01). In terms of the cancer type subgroup analysis, combined correlation coefficients of ADC/SUV range from −0.12
(lymphoma, 𝑛 = 5) to −0.59 (pancreatic cancer, 𝑛 = 2). We concluded that there is an average negative correlation between ADC and
SUV in patients with cancer. Higher correlations were found in the brain tumor, cervix carcinoma, and pancreas cancer. However,
a larger, prospective study is warranted to validate these findings in different cancer types.
