Author/Authors :
Bruter, A.V Institute of Gene Biology - Russian Academy of Sciences, Moscow, Russia , Rodionova, M.D ITMO University, Saint-Petersburg, Russia , Varlamova, E.A Institute of Gene Biology - Russian Academy of Sciences, Moscow, Russia , Shtil, A.A Institute of Gene Biology - Russian Academy of Sciences, Moscow, Russia
Abstract :
Super-enhancers (genome elements that activate gene transcription) are DNA regions with an elevat-ed concentration of transcriptional complexes. These multiprotein structures contain, among other components, the cyclin-dependent kinases 8 and 19. These and other transcriptional protein kinases are regarded as novel targets for pharmacological inhibition by antitumor drug candidates.
Keywords :
tumors , targeted therapy , transcriptional protein kinases , super-enhancers , transcription
