Title of article :
A Library of Potential Nanoparticle Contrast Agents for X-Ray Fluorescence Tomography Bioimaging
Author/Authors :
Li, Yuyang Department of Applied Physics - Biomedical and X-ray Physics - KTH Royal Institute of Technology/Albanova - Stockholm, Sweden , Shaker, Kian Department of Applied Physics - Biomedical and X-ray Physics - KTH Royal Institute of Technology/Albanova - Stockholm, Sweden , Larsson, Jakob C Department of Applied Physics - Biomedical and X-ray Physics - KTH Royal Institute of Technology/Albanova - Stockholm, Sweden , Vogt, Carmen Department of Applied Physics - Biomedical and X-ray Physics - KTH Royal Institute of Technology/Albanova - Stockholm, Sweden , Hertz, Hans M Department of Applied Physics - Biomedical and X-ray Physics - KTH Royal Institute of Technology/Albanova - Stockholm, Sweden , Toprak, Muhammet S Department of Applied Physics - Biomedical and X-ray Physics - KTH Royal Institute of Technology/Albanova - Stockholm, Sweden
Abstract :
Nanoparticles (NPs) have been used as contrast agents for several bioimaging modalities. X-ray fluorescence (XRF) tomography
can provide sensitive and quantitative 3D detection of NPs. With spectrally matched NPs as contrast agents, we demonstrated
earlier in a laboratory system that XRF tomography could achieve high-spatial-resolution tumor imaging in mice. Here, we
present the synthesis, characterization, and evaluation of a library of NPs containing Y, Zr, Nb, Rh, and Ru that have spectrally
matched K-shell absorption for the laboratory scale X-ray source. e K-shell emissions of these NPs are spectrally well separated
from the X-ray probe and the Compton background, making them suitable for the lab-scale XRF tomography system. Their
potential as XRF contrast agents is demonstrated successfully in a small-animal equivalent phantom, conrming the simulation
results. e diversity in the NP composition provides a flexible platform for a better design and biological optimization of XRF
tomography nanoprobes.
Keywords :
Bioimaging , X-Ray , Tomography , CT
Journal title :
Contrast Media and Molecular Imaging
