Author/Authors :
Augusto KAzAn de oliveirA, Felipe Universidade Estadual de São Paulo Júlio de Mesquita Filho (UNESP) - Faculdade de Medicina de Botucatu, Botucatu, SP, Brazil , FernAndo eloi pinto, Fábio Universidade Estadual de São Paulo Júlio de Mesquita Filho (UNESP) - Faculdade de Medicina de Botucatu, Botucatu, SP, Brazil , sArdenberg, trAjAno Universidade Estadual de São Paulo Júlio de Mesquita Filho (UNESP) - Faculdade de Medicina de Botucatu, Botucatu, SP, Brazil , josé CAção pereirA, gilberto Universidade Estadual de São Paulo Júlio de Mesquita Filho (UNESP) - Faculdade de Medicina de Botucatu, Botucatu, SP, Brazil , CArlos CurCelli, emílio Universidade Estadual de São Paulo Júlio de Mesquita Filho (UNESP) - Faculdade de Medicina de Botucatu, Botucatu, SP, Brazil , pennA, vAlter Universidade Estadual de São Paulo Júlio de Mesquita Filho (UNESP) - Faculdade de Medicina de Botucatu, Botucatu, SP, Brazil
Abstract :
Paget’s disease of bone is a chronic condition characterized by focal
abnormalities of absorption and formation of bone, and it may lead to
anatomical deformities, pain, fractures, and malignant transformation.
It is common in the UK, Australia, New Zealand, and North America
and has a strong hereditary component, affecting first- to third-degree
relatives. The etiology remains unclear and treatment is based on
control of the disease with bisphosphonates, with the aim of relieving
symptoms and correcting laboratory abnormalities. Surgical treatment
may also be necessary to correct deformities or treat pathological
fractures. This study evaluated the management and course of 8
patients with Paget’s disease of bone, followed in the Orthopedic Clinic
of this hospital. Among these patients, 1 had concomitant advanced
prostate carcinoma, highlighting the association between Paget’s
disease and secondary bone diseases that can affect the differential
diagnosis. Level of evidence IV, Study type: Case Series.
