Author/Authors :
Tanifum, Eric A Department of Radiology - Baylor College of Medicine - Houston, USA , Devkota, Laxman Department of Radiology - Baylor College of Medicine - Houston, USA , Ngwa, Conelius Department of Radiology - Baylor College of Medicine - Houston, USA , Badachhape, Andrew A Department of Radiology - Baylor College of Medicine - Houston, USA , Ghaghada, Ketan B Department of Radiology - Baylor College of Medicine - Houston, USA , Romero, Jonathan Department of Molecular Physiology and Biophysics - Baylor College of Medicine, USA , Pautler, Robia G Department of Radiology - Baylor College of Medicine - Houston, USA , Annapragada, Ananth V Department of Radiology - Baylor College of Medicine - Houston, USA
Abstract :
Fluorine-19 (19F) magnetic resonance imaging (MRI) has the potential for a wide range of in vivo applications but is limited by lack
of flexibility in exogenous probe formulation. Most 19F MRI probes are composed of perfluorocarbons (PFCs) or per-
fluoropolyethers (PFPEs) with intrinsic properties which limit formulation options. Hydrophilic organofluorine molecules can
provide more flexibility in formulation options. We report herein a hyperfluorinated hydrophilic organoflourine, ET1084, with
∼24 wt. % 19F content. It dissolves in water and aqueous buers to give solutions with ≥8 M 19F. 19F MRI phantom studies at 9.4T
employing a 10-minute multislice multiecho (MSME) scan sequence show a linear increase in signal-to-noise ratio (SNR) with
increasing concentrations of the molecule and a detection limit of 5 mM. Preliminary cytotoxicity and genotoxicity assessments
suggest it is safe at concentrations of up to 20 mM.
