Author/Authors :
Tran, Vu-Long Univ Lyon - Universite Claude Bernard Lyon - Institut Lumiere Matiere - Lyon, France , Thakare, Vivek Institut de Chimie Moleculaire de l’Universite de Bourgogne (ICMUB) - Universite de Bourgogne Franche-Comte - 9 Avenue Alain Savary - Dijon, France , Natuzzi, Marco Univ Lyon - Universite Claude Bernard Lyon - Institut Lumiere Matiere - Lyon, France , Moreau, Mathieu Institut de Chimie Moleculaire de l’Universite de Bourgogne (ICMUB) - Universite de Bourgogne Franche-Comte - 9 Avenue Alain Savary - Dijon, France , Oudot, Alexandra Plateforme d’Imagerie et Radiotherapie Precliniques - Medecine Nucleaire - Georges-Francois LECLERC Cancer Center-UNICANCER - Dijon, France , Vrigneaud, Jean-Marc Plateforme d’Imagerie et Radiotherapie Precliniques - Medecine Nucleaire - Georges-Francois LECLERC Cancer Center-UNICANCER - Dijon, France , Courteau, Alan Plateforme d’Imagerie et Radiotherapie Precliniques - Medecine Nucleaire - Georges-Francois LECLERC Cancer Center-UNICANCER - Dijon, France , Louis, Cedric Nano-H - Place de l’Europe - Saint Quentin Fallavier, France , Roux, Stephane Institut UTINAM - Universite de Bourgogne Franche-Comte - Route de Gray - Besançon, France , Boschetti, Frederic CheMatech - 2 rue Pauline Kergomard - Dijon, France , Denat, Franck Institut de Chimie Moleculaire de l’Universite de Bourgogne (ICMUB) - Universite de Bourgogne Franche-Comte - 9 Avenue Alain Savary - Dijon, France , Tillement, Olivier Univ Lyon - Universite Claude Bernard Lyon - Institut Lumiere Matiere - Lyon, France , Lux, François Univ Lyon - Universite Claude Bernard Lyon - Institut Lumiere Matiere - Lyon, France
Abstract :
Multimodal nanoprobes are highly demanded for biomedical imaging applications to enhance the reliability of the diagnostic
results. Among difierent types of nano-objects, ultrasmall silica gadolinium nanoparticle (SiGdNP) appears as a safe, efiective,
and versatile platform for this purpose. In this study, a new method to functionalize SiGdNP based on silane chemistry has been
reported. Two types of chelating silanes (APTES-DOTAGA and APTES-NODAGA) have been synthesized and grafted on
SiGdNP by a simple one-step protocol. This functionalization strategy requires no other reactants or catalyzers and does not
compromise the ultrasmall size of the particles. NODAGA-functionalized particle has been labeled with 64Cu isotope and
injected intravenously to mice bearing TS/A carcinoma tumor for biodistribution study to demonstrate its potential as
a bimodal MRI/PET imaging agent. A fully integrated MRI/PET system was used to simultaneously monitor the distribution of
the particle. The results showed that the functionalized particle maintained properties of a renal clearable NP which could
rapidly escape through kidneys and had low retention in other organs, especially liver, even though its accumulation in the
tumor was modest.
Keywords :
Gadolinium , MRI/64Cu , PET , MRI
