Author/Authors :
Potì, Francesco Department of Medicine and Surgery – Unit of Neurosciences - University of Parma, Parma, Italy , Pozzoli, Cristina Department of Medicine and Surgery – Unit of Neurosciences - University of Parma, Parma, Italy , Adami, Maristella Department of Medicine and Surgery – Unit of Neurosciences - University of Parma, Parma, Italy , Poli, Enzo Department of Medicine and Surgery – Unit of Neurosciences - University of Parma, Parma, Italy , Costa, Lucio G. Department of Medicine and Surgery – Unit of Neurosciences - University of Parma, Parma, Italy
Abstract :
The Coronavirus disease 19 (COVID-19) outbreak has been recognized as a global threat to public health. It is caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and no effective therapies currently exist against this novel viral agent.Along with extensive public health measures, an un-precedented global effort in identifying effective drugs for the treatment is being implemented. Potential drug targets are emerging as the result of a fast-evolving understanding of SARS-CoV-2 virology, host response to the infection, and clinical course of the disease. This brief review focuses on the latest and most promising pharmacological treatments against COVID-19 currently under investigation and discuss their potential use based on either documented efficacy in similar viral infections, or their activity against inflammatory syn-dromes. Ongoing clinical trials are also emphasized. (www.actabiomedica.it)
Keywords :
COVID-19 , SARS-CoV-2 , drugs , therapy , antivirals , inflammation
