Title of article :
Crystal structure of a nucleoside model for the interstrand cross-link formed by the reaction of 2′-deoxyguanosine and an abasic site in duplex DNA
Author/Authors :
Catalano, Michael J. 125 Chemistry Bldg - University of Missouri-Columbia, USA , Ruddraraju, Kasi Viswanatharaju 125 Chemistry Bldg - University of Missouri-Columbia, USA , Barnesa, Charles L. 125 Chemistry Bldg - University of Missouri-Columbia, USA , Gatesa, Kent S. 125 Chemistry Bldg - University of Missouri-Columbia, USA
Abstract :
The title compound, 9-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl]-2-{[(2R,4S,5R)-4-methoxy-5-(methoxymethyl)tetrahydrofuran-2-yl]amino}-1H-purin-6(9H)-one, C17H25N5O7, crystallizes with two independent molecules (A and B) in the asymmetric unit. In the crystal, the guanosine moieties of molecules A and B are linked by N—H⋯N and O—H⋯N hydrogen-bonding interactions, forming ribbons which are stacked to form columns along [100]. These columns are then linked by O—H⋯O hydrogen bonds between the ribose moieties and numerous C—H⋯O interactions to complete the three-dimensional structure.
Keywords :
hydrogen bonding , nucleobase , crystal structure , glycosidic linkage , deoxy-D-ribofuranose , 2′-deoxyguanosine , purine-6(9H)-one
Journal title :
Acta Crystallographica Section E: Crystallographic Communications
