Author/Authors :
Sun, Lu Department of Neurosurgery - PLA General Hospital - Haidian District - Beijing, China , Zhou, Kedi Department of Biomedical Engineering - College of Engineering - Peking University - Haidian District - Beijing, China , Wang, Weijun Department of Neurosurgery - PLA General Hospital - Haidian District - Beijing, China , Zhang, Xiaojun Department of Nuclear Medicine - PLA General Hospital - Haidian District - Beijing, China , Ju, Zhongjian Department of Radiation Oncology - PLA General Hospital - Haidian District - Beijing, China , Qu, Baolin Department of Radiation Oncology - PLA General Hospital - Haidian District - Beijing, China , Zhang, Zhizhong Department of Neurosurgery - PLA General Hospital - Haidian District - Beijing, China , Wang, Jinyuan Department of Radiation Oncology - PLA General Hospital - Haidian District - Beijing, China , Ling, Zhipei Department of Neurosurgery - PLA General Hospital - Haidian District - Beijing, China , Yu, Xinguang Department of Neurosurgery - PLA General Hospital - Haidian District - Beijing, China , Zhang, Jinming Department of Nuclear Medicine - PLA General Hospital - Haidian District - Beijing, China , Pan, Longsheng Department of Neurosurgery - PLA General Hospital - Haidian District - Beijing, China
Abstract :
[18F]ML-10 is a novel apoptosis radiotracer for positron emission tomography (PET). We assess the apoptosis response of
intracranial tumor early after CyberKnife (CK) treatment by [18F]ML-10 PET imaging. 29 human subjects (30 lesions), diagnosed
with intracranial tumors, underwent CK treatment at 14–24 Gy in 1–3 fractions, had [18F]ML-10 positron emission
tomography/computed tomography (PET/CT) before (pre-CK) and 48 hours after (post-CK) CK treatment. Magnetic resonance
imaging (MRI) scans were taken before and 8 weeks after CK treatment. Voxel-based analysis was used for the imaging analysis.
Heterogeneous changes of apoptosis in tumors before and after treatment were observed on voxel-based analysis of PETimages. A
positive correlation was observed between the change in radioactivity (X) and subsequent tumor volume (Y) (r = 0.862, p < 0.05),
with a regression equation of Y = 1.018=X 0.016. Malignant tumors tend to be more sensitive to CK treatment, but the treatment
outcome is not a£ected by pre-CK apoptotic status of tumor cells; [18F]ML-10 PET imaging could be taken as an assessment 48 h
after CK treatment.
