Title of article :
Evans Blue Dye: A Revisit of Its Applications in Biomedicine
Author/Authors :
Yao, Linpeng Department of Radiology - Te First Afliated Hospital - Zhejiang University School of Medicine - 79 Qingchun Road - Hangzhou - Zhejiang, China , Xue, Xing Department of Radiology - Te First Afliated Hospital - Zhejiang University School of Medicine - 79 Qingchun Road - Hangzhou - Zhejiang, China , Yu, Peipei Department of Radiology - Te First Afliated Hospital - Zhejiang University School of Medicine - 79 Qingchun Road - Hangzhou - Zhejiang, China , Ni, Yicheng University Hospitals - University of Leuven - Leuven, Belgium , Chen, Feng Department of Radiology - Te First Afliated Hospital - Zhejiang University School of Medicine - 79 Qingchun Road - Hangzhou - Zhejiang, China
Abstract :
Evans blue (EB) dye has owned a long history as a biological dye and diagnostic agent since its frst staining application by Herbert
McLean Evans in 1914. Due to its high water solubility and slow excretion, as well as its tight binding to serum albumin, EB has been
widely used in biomedicine, including its use in estimating blood volume and vascular permeability, detecting lymph nodes, and
localizing the tumor lesions. Recently, a series of EB derivatives have been labeled with PET isotopes and can be used as theranostics
with a broad potential due to their improved half-life in the blood and reduced release. Some of EB derivatives have even been used
in translational applications in clinics. In addition, a novel necrosis-avid feature of EB has recently been reported in some preclinical
animal studies. Given all these interesting and important advances in EB study, a comprehensive revisiting of EB has been made in
its biomedical applications in the review.
Keywords :
Blue , Biomedicine , EB , Given
Journal title :
Contrast Media and Molecular Imaging
