Author/Authors :
Guler, Serkan Aksaray University - Faculty of Medicine - Department of Ortopaedic and Traumatology, Aksaray, Turkey , Akcali, Omer Dokuz Eylul University - Faculty of Medicine - Department of Ortopaedic and Traumatology, Izmir, Turkey , Sen, Baran C Dokuz Eylul University - Faculty of Medicine - Department of Ortopaedic and Traumatology, Izmir, Turkey , ilaker Micili, Serap Dokuz Eylul University - Faculty of Medicine - Department of Histology, Izmir, Turkey , Kemal Sanli, Namık Dokuz Eylul University - Faculty of Medicine - Department of Haematology and Oncology, Izmir, Turkey , Cankaya, Deniz Aksaray University - Faculty of Medicine - Department of Ortopaedic and Traumatology, Aksaray, Turkey
Abstract :
Objective: Epidural fibrosis is one of the main reasons for requiring
repeated surgical intervention. Our objective was to compare the
effect of Platelet Rich Plasma (PRP) on the development of epidural
fibrosis with collagen dural matrix and free autogenous fat graft.
Methods: Male rats were separated into 3 groups. Laminectomy was
implemented on the rats and epidural fat pad was placed in the first
group (n = 7); equal size of collagen dural matrix was applied in the
second group (n = 7); a single dose of PRP was applied in the third
group (n = 7). Results: Epidural fibrosis was more common in the
group that collagen dural matrix was applied when compared the
ones that PRP was applied. PRP group presented better values in
preventing epidural fibrosis when compared to the fat pad group,
however this difference was not statistically significant. Conclusion:
PRP is a material that can be easily obtained from the very blood of
patients and at an extremely low cost; the main clinical relevance of
our study is that the PRP might be an efficient material for better clinical
results after laminectomy surgery due to its tissue healing and epidural
fibroris preventing potentials. Level of Evidence V, Animal research
Keywords :
Platelet-Rich Plasma , Laminectomy , Fibrosis , Collagen
