Author/Authors :
Lankinen, Petteri Department of Orthopaedics and Traumatology - Turku University Hospital - Turku, Finland , Noponen, Tommi Department of Clinical Physiology and Nuclear Medicine - Turku University Hospital and University of Turku - Turku, Finland , Autio, Anu University of Turku - Turku, Finland , Luoto, Pauliina University of Turku - Turku, Finland , Frantzèn, Janek Department of Neurosurgery - Turku University Hospital - Turku, Finland , Löyttyniemi, Eliisa Department of Biostatistics - University of Turku - Turku, Finland , Hakanen, Antti J Department of Clinical Microbiology - Turku University Hospital and Medical Microbiology and Immunology - University of Turku - Turku, Finland , Aro, Hannu T. Department of Orthopaedics and Traumatology - Turku University Hospital - Turku, Finland , Roivainen, Anne University of Turku - Turku, Finland
Abstract :
There may be some diferences in the in vivo behavior of 68Ga-chloride and 68Ga-citrate leading to diferent accumulation profles.
Tis study compared 68Ga-citrate and 68Ga-chloride PET/CT imaging under standardized experimental models. Methods. Difuse
Staphylococcus aureus tibial osteomyelitis and uncomplicated bone healing rat models were used (n = 32). Two weeks afer surgery,
PET/CT imaging was performed on consecutive days using 68Ga-citrate or 68Ga-chloride, and tissue accumulation was confrmed
by ex vivo analysis. In addition, peripheral quantitative computed tomography and conventional radiography were performed.
Osteomyelitis was verifed by microbiological analysis and specimens were also processed for histomorphometry. Results. In
PET/CT imaging, the SUVmax of 68Ga-chloride and 68Ga-citrate in the osteomyelitic tibias (3.6 ± 1.4 and 4.7 ± 1.5, resp.) were
signifcantly higher (p = 0.0019 and p = 0.0020, resp.) than in the uncomplicated bone healing (2.7 ± 0.44 and 2.5 ± 0.49, resp.). In
osteomyelitic tibias, the SUVmax of 68Ga-citrate was signifcantly higher than the uptake of 68Ga-chloride (p = 0.0017). In animals
with uncomplicated bone healing, no diference in the SUVmax of 68Ga-chloride or 68Ga-citrate was seen in the operated tibias.
Conclusions. This study further corroborates the use of 68Ga-citrate for PET imaging of osteomyelitis.
