Author/Authors :
Du, Xiaoqing Department of Nuclear Medicine - Afliated Hospital of Jiangnan University (Wuxi No. 4 People’s Hospital) - Wuxi, China , Zhang, Yu Department of Nuclear Medicine - Afliated Hospital of Jiangnan University (Wuxi No. 4 People’s Hospital) - Wuxi, China , Chen, Liping Department of Nuclear Medicine - Afliated Hospital of Jiangnan University (Wuxi No. 4 People’s Hospital) - Wuxi, China , Mi, Baoming Department of Nuclear Medicine - Afliated Hospital of Jiangnan University (Wuxi No. 4 People’s Hospital) - Wuxi, China , You, Qingjun Department of Nuclear Medicine - Afliated Hospital of Jiangnan University (Wuxi No. 4 People’s Hospital) - Wuxi, China , Xu, Yuping Ministry of Health - Jiangsu Institute of Nuclear Medicine - Wuxi, China , Pan, Donghui Ministry of Health - Jiangsu Institute of Nuclear Medicine - Wuxi, China , Wan, Weixing Department of Nuclear Medicine - Afliated Hospital of Jiangnan University (Wuxi No. 4 People’s Hospital) - Wuxi, China , Yang, Min Ministry of Health - Jiangsu Institute of Nuclear Medicine - Wuxi, China , Yu, Chunjing Department of Nuclear Medicine - Afliated Hospital of Jiangnan University (Wuxi No. 4 People’s Hospital) - Wuxi, China
Abstract :
To compare the diferential diagnostic values of 18F-Alfatide II PET/CT between tuberculosis and lung cancer patients and
in patients with sarcoidosis and common infammation. Methods. Nine infammation patients (4 tuberculosis, 3 sarcoidosis, and 2
common infammation) and 11 lung cancer patients were included in this study. All patients underwent 18F-FDG and 18F-Alfatide II
PET/CT within 2 weeks, followed by biopsy and surgery. The maximized standard uptake value (SUVmax) and the mean standard
uptake value (SUVmean) were evaluated. Results. The active tuberculosis lesions showed a high accumulation of 18F-FDG, but
varying degrees of accumulation of 18F-Alfatide II, including negative results. The SUVmax of 18F-Alfatide II in malignant lesions
was signifcantly higher than that in tuberculosis (4.08 ± 1.51 versus 2.63 ± 1.34, p = 0.0078). Tree patients with sarcoidosis showed
negative results in 18F-Alfatide II PET/CT. Conclusions. The expression of αVβ3 is much lower in tuberculosis as compared to that
in lung cancer, and accumulation of 18F-Alfatide II varied even in lesions of the same patient. The negative results of sarcoidosis
patients led to the speculation that αVβ3 was not expressed in those lesions.
