Author/Authors :
Huang, Mengqi Department of Radiology - The First Affiliated Hospital - Sun Yat-Sen University - 58 Second Zhongshan Road - Guangzhou - Guangdong, China , Liao, Bing Department of Pathology - The First Affiliated Hospital - Sun Yat-Sen University - 58 Second Zhongshan Road - Guangzhou - Guangdong, China , Xu, Ping Department of Radiology - The First Affiliated Hospital - Sun Yat-Sen University - 58 Second Zhongshan Road - Guangzhou - Guangdong, China , Cai, Huasong Department of Radiology - The First Affiliated Hospital - Sun Yat-Sen University - 58 Second Zhongshan Road - Guangzhou - Guangdong, China , Huang, Kun Department of Radiology - The First Affiliated Hospital - Sun Yat-Sen University - 58 Second Zhongshan Road - Guangzhou - Guangdong, China , Dong, Zhi Department of Radiology - The First Affiliated Hospital - Sun Yat-Sen University - 58 Second Zhongshan Road - Guangzhou - Guangdong, China , Xu, Ling Faculty of Medicine and Dentistry - University of Western Australia - Perth, Australia , Peng, Zhenpeng Department of Radiology - The First Affiliated Hospital - Sun Yat-Sen University - 58 Second Zhongshan Road - Guangzhou - Guangdong, China , Luo, Yanji Department of Radiology - The First Affiliated Hospital - Sun Yat-Sen University - 58 Second Zhongshan Road - Guangzhou - Guangdong, China , Zheng, Keguo Department of Radiology - The First Affiliated Hospital - Sun Yat-Sen University - 58 Second Zhongshan Road - Guangzhou - Guangdong, China , Peng, Baogang Department of Hepatobiliary Surgery - The First Affiliated Hospital - Sun Yat-Sen University - 58 Second Zhongshan Road - Guangzhou - Guangdong, China , Li, Zi-Ping Department of Radiology - The First Affiliated Hospital - Sun Yat-Sen University - 58 Second Zhongshan Road - Guangzhou - Guangdong, China , Feng, Shi-Ting Department of Radiology - The First Affiliated Hospital - Sun Yat-Sen University - 58 Second Zhongshan Road - Guangzhou - Guangdong, China
Abstract :
To investigate the imaging features observed in preoperative Gd-EOB-DTPA-dynamic enhanced MRI and correlated
with the presence of microvascular invasion (MVI) in hepatocellular carcinoma (HCC) patients. Methods. 66 HCCs in 60 patients
with preoperative Gd-EOB-DTPA-dynamic enhanced MRI were retrospectively analyzed. Features including tumor size, signal
homogeneity, tumor capsule, tumor margin, peritumor enhancement during mid-arterial phase, peritumor hypointensity during
hepatobiliary phase, signal intensity ratio on DWI and apparent difusion coefcients (ADC), T1 relaxation times, and the reduction
rate between pre- and postcontrast enhancement images were assessed. Correlation between these features and histopathological
presence of MVI was analyzed to establish a prediction model. Results. Histopathology confrmed that MVI were observed in
17 of 66 HCCs. Univariate analysis showed tumor size (p = 0.003), margin (p = 0.013), peritumor enhancement (p = 0.001),
and hypointensity during hepatobiliary phase (p = 0.004) were associated with MVI. A multiple logistic regression model was
established, which showed tumor size, margin, and peritumor enhancement were combined predictors for the presence of MVI
(α = 0.1). R2 of this prediction model was 0.353, and the sensitivity and specifcity were 52.9% and 93.0%, respectively. Conclusion.
Large tumor size, irregular tumor margin, and peritumor enhancement in preoperative Gd-EOB-DTPA-dynamic enhanced MRI
can predict the presence of MVI in HCC.
