Author/Authors :
Fu, Jia-Wei South China Normal University - Guangzhou, China , Lin, Yi-Sheng Department of Radiology, The First Affiliated Hospital - Guangzhou University of Traditional Chinese Medicine - Guangzhou - Guangdong, China , Gan, Sheng-Long South China Normal University - Guangzhou, China , Li, Yong-Rui South China Normal University - Guangzhou, China , Wang, Yao South China Normal University - Guangzhou, China , Feng, Shi-Ting Department of Radiology, The First Affiliated Hospital - Sun Yat-Sen University - Guangzhou, China , Li, Hao South China Normal University - Guangzhou, China , Zhou, Guo-Fu South China Normal University - Guangzhou, China
Abstract :
In ultrasonography, ultrasound contrast agents (UCAs) that possess high acoustic impedance mismatch with the bulk medium are
frequently employed to highlight the borders between tissues by enhanced ultrasound scattering in a clinic. Typically, the most
common UCA, microbubble, is generally close in size to a red blood cell (<∼10 μm). These microscale UCAs cannot be directly
entrapped into the target cells but generate several orders of magnitude stronger echo signals than the nanoscale ones. and their
large containment and high ultrasound responsiveness also greatly facilitate to perform combined treatments, e.g., drug delivery
and other imaging techniques. So multifunctionalized microscale UCAs appear on this scene and keep growing toward a
promising direction for precise theranostics. In this review, we systematically summarize the new advances in the principles and
preparations of multifunctionalized microscale UCAs and their medical applications for malignant tumors.
Keywords :
Multifunctionalized , Theranostics , Tumor , UCA
