Author/Authors :
Li, Ying Department of Epidemiology and Health Statistics - School of Public Health - Guangdong Pharmaceutical University, Guangzhou, China , Lin, Jialing School of Population Health - the University of New South Wales, Sydney, Australia , Li, Linghua Department of Infectious Diseases - Guangzhou Eighth People’s Hospital - Guangzhou Medical University, Guangzhou, China , Cai, Weiping Department of Infectious Diseases - Guangzhou Eighth People’s Hospital - Guangzhou Medical University, Guangzhou, China , Ye, Jiaping Department of Preventive Health Care - Beihai People’s Hospital, Beihai, China , He, Suiping Department of Epidemiology and Health Statistics - School of Public Health - Guangdong Pharmaceutical University, Guangzhou, China , Zhang, Wencui Department of Epidemiology and Health Statistics - School of Public Health - Guangdong Pharmaceutical University, Guangzhou, China , Liu, Ning Department of Epidemiology and Health Statistics - School of Public Health - Guangdong Pharmaceutical University, Guangzhou, China , Gong, Zijun Department of Epidemiology and Health Statistics - School of Public Health - Guangdong Pharmaceutical University, Guangzhou, China , Ye, Xiaohua Department of Epidemiology and Health Statistics - School of Public Health - Guangdong Pharmaceutical University, Guangzhou, China , Yao, Zhenjiang Department of Epidemiology and Health Statistics - School of Public Health - Guangdong Pharmaceutical University, Guangzhou, China
Abstract :
Background
Methicillin-resistant coagulase-negative Staphylococci (MRCoNS) is regarded as the repository of mecA gene for methicillin-resistant Staphylococcus aureus (MRSA) and may develop methicillin-susceptible Staphylococcus aureus (MSSA) to MRSA. Therefore, we aimed to explore whether MRCoNS carriage is a risk factor of MRSA colonization. Phenotypic characteristics were performed to further assess the associations between MRSA and MRCoNS.
Methods
This cross-sectional study was conducted in Guangzhou, China. Participants completed a questionnaire and provided a nasal swab for further analysis. The risk factors of MRSA colonization were analyzed using nonconditional logistic regression models. The phenotypic characteristics between MRSA and MRCoNS were compared by Chi-square test.
Results
Among the 1001 HIV-infected patients, a total of 119 (11.89%) participants were positive for MRSA, and 34.45% (41/119) of all MRSA carriers were positive for MRCoNS. We found MRCoNS carriage was a protective factor of MRSA colonization (adjusted odds ratio = 0.59, 95% confidence interval: 0.38–0.91). A significant difference in the proportions of antibiotic resistance between MRSA and MRCoNS isolates was found except for penicillin, clindamycin, tetracycline, and teicoplanin. The main STs and CC types of MRSA isolates in this population were ST188 (15.1%) and CC59 (17.6%), respectively.
Conclusions
HIV-infected patients remain a highly vulnerable population for MRSA colonization. Though who carried MRCoNS is less likely to have MRSA colonization, similarity of some antibiotic resistance between MRSA and MRCoNS was found in this study. Regular surveillance on the colonization and antibiotic patterns of MRSA and MRCoNS is still necessary.
Keywords :
Methicillin-Resistant , Coagulase-Negative Staphylococci , Protective Factor , Methicillin-Resistant Staphylococcus
