Author/Authors :
Xu, Lian Department of Nuclear Medicine - Ren Ji Hospital - School of Medicine - Shanghai Jiao Tong University - Shanghai, China , Shi, Yiping Department of Nuclear Medicine - Ren Ji Hospital - School of Medicine - Shanghai Jiao Tong University - Shanghai, China , Wang, Yining Department of Nuclear Medicine - Ren Ji Hospital - School of Medicine - Shanghai Jiao Tong University - Shanghai, China , Zhou, Xiang Department of Nuclear Medicine - Ren Ji Hospital - School of Medicine - Shanghai Jiao Tong University - Shanghai, China , Huang, Gan Department of Nuclear Medicine - Ren Ji Hospital - School of Medicine - Shanghai Jiao Tong University - Shanghai, China , Chen, Ruohua Department of Nuclear Medicine - Ren Ji Hospital - School of Medicine - Shanghai Jiao Tong University - Shanghai, China , Liu, Jianjun Department of Nuclear Medicine - Ren Ji Hospital - School of Medicine - Shanghai Jiao Tong University - Shanghai, China
Abstract :
Urachal carcinoma is a rare urological malignancy. Use of 18F-FDG PET/CT in urological oncology has developed slowly
because of the urinary elimination of 18F-FDG. We investigated whether delayed postdiuretic 18F-FDG PET/CT could be used for
diagnosing urachal carcinoma. Methods. This retrospective study included 6 patients who underwent delayed postdiuretic 18F-FDG
PET/CT for the evaluation of urachal carcinoma. The delayed postdiuretic PET/CT parameters and clinical characteristics of urachal
carcinoma were investigated. Results. There was no significant difference in the SUVmax between the primary tumors and the urine in
the bladder before delayed diuresis (25.4±19.5 vs. 42.9±31.1, P = 0.18). However, the SUVmax of the primary tumors was significantly
higher than the SUVmax of urine after delayed diuresis (25.4±19.5 vs. 3.5 ±1.6, P = 0.002). Diuretic 18F-FDG PET/CT was positive in
all patients when compared with normal liver tissues or urine after delayed diuresis..e SUVmax, TLR, and TUR of the primary tumors
were 25.4 (range: 7.2–58.9), 7.0 (range: 1.8–14.7), and 6.8 (range: 3.8–11.3), respectively. Delayed postdiuretic 18F-FDG PET/CT had a
negative predictive value of 100% (5/5) for predicting lymph node metastasis. One patient received chemotherapy after radical resection
of urachal carcinoma because 18F-FDG PET/CTfound lung metastases, and one patient only received chemotherapy because PET/CT
found peritoneal and skeletal metastases. Conclusions. Delayed postdiuretic 18F-FDG PET/CT is a useful tool for the preoperative
evaluation of urachal carcinoma. 18F-FDG PET/CT may improve clinical decision making and management of urachal carcinomas.
