Title of article :
Proliferation, angiogenesis and differentiation related markers in compact and follicular-compact thyroid carcinomas in dogs
Author/Authors :
pessina, p. universidad de la república - facultad de veterinaria - laboratorio de técnicas nucleares, Uruguay , castillo, v.a. universidad de buenos aires - escuela medicina veterinaria, facultad de ciencias veterinarias - cat. clin. méd. peq. an. and u. endocrinología, Argentina , césar, d. instituto plan agropecuario, Uruguay , sartore, i. universidad de la república - facultad de veterinaria - laboratorio de técnicas nucleares, Uruguay , meikle, a. universidad de la república - facultad de veterinaria - laboratorio de técnicas nucleares, Uruguay
Abstract :
Immunohistochemical markers (IGF-1, IGF-1R, VEGF, FGF-2, RARα and RXR) were evaluated in healthy canine thyroid glands (n=8) and in follicular-compact (n=8) and compact thyroid carcinomas (n=8). IGF-1, IGF-1R and VEGF expression was higher in fibroblasts and endothelial cells of compact carcinoma than in healthy glands (P 0.05). Compared to follicular-compact carcinoma, compact carcinoma had higher IGF-1R expression in fibroblasts, and higher FGF-2 expression in endothelial cells (P 0.05). RARα expression was higher in endothelial cells of compact carcinoma than in those of other groups (P 0.05). The upregulation of these proliferation- and angiogenesis-related factors in endothelial cells and/or fibroblasts and not in follicular cells of compact carcinoma compared to healthy glands supports the relevance of stromal cells in cancer progression.
Keywords :
Canine , Histology , Immunohistochemistry , Thyroid carcinoma
Journal title :
Open Veterinary Journal
Journal title :
Open Veterinary Journal
