Title of article :
The Effects of 3,4-methylenedioxy- methamphetamine on Neurogenesis in the Hippocampus of Male Rats
Author/Authors :
Soleimani Asl ، Sara Endometrium and Endometriosis Research Centre - Hamadan University of Medical Sciences , Ghasemi Moravej ، Fahimeh Endometrium and Endometriosis Research Centre - Hamadan University of Medical Sciences , Kowsari ، Golshad School of Advanced Technologies in Medicine - Iran University of Medical Sciences , Farhadi ، Mohammad Hassan Subsance Abuse and Dependence Research Center - University of Social Welfare and Rehabilitation Sciences , Pourhaydar ، Bagher Department of Anatomy - Neurophysiology Research Center, School of Medicine - Urmia University of Medical Sciences , Ghasemi Hamidabadi ، Hatef Department of Anatomy and Cell Biology - School of Medicine - Mazandaran University of Medical Sciences , Mehdizadeh ، Mehdi Department of Anatomy - Cellular and Molecular Research Center, School of Medicine - Iran University of Medical Sciences
Abstract :
Introduction: The administration of 3,4-methylenedioxymethamphetamine (MDMA) or ecstasy causes memory impairment, whereas neurogenesis improves memory and learning. Hence, this study evaluated the effects of MDMA on neurogenesis in the hippocampus of male rats. Methods: Adult male Wistar rats received Intraperitoneal (IP) injections of MDMA (10 mg/ kg). We assessed nestin, sex-determining region Y-box 2 (Sox2), and NeuroD expressions according to the immunohistochemistry analyses. Results: MDMA reduced the expressions of nestin, Sox2, and NeuroD compared with the control groups. The reduction in NeuroD expression was age-related. Conclusion: MDMA possibly has negative effects on neurogenesis, which specifically results from impaired survival of newborn cells.
Keywords :
N , Methyl , 3 , 4 , methylenedioxyamphetamine , Hippocampus , Nestin , Sox2 Protein , NeuroD Protein
Journal title :
Basic and Clinical Neuroscience
Journal title :
Basic and Clinical Neuroscience
