Author/Authors :
Wang, Enzhi Taizhou Integrated Chinese and Western Medicine Hospital - Department of Clinical Laboratory, Taizhou, Zhejiang, China , Lin, Jianjun Ningbo Fourth Hospital - Department of Clinical Laboratory, Ningbo, Zhejiang, China , Xu, Guangwei Ningbo Women and Children’s Hospital - Department of Orthopedics, Ningbo, Zhejiang, China , Wang, Xinhua Taizhou Integrated Chinese and Western Medicine Hospital - Department of Clinical Laboratory, Taizhou, Zhejiang, China , Chen, Mifang Ningbo Women and Children’s Hospital - Department of Clinical Laboratory, Ningbo, Zhejiang, China
Abstract :
Objective: This study sought to determine serum sclerostin (SOST)
expression in patients with osteoporotic thoracolumbar vertebral
compression fractures before and after percutaneous kyphoplasty
(PKP). Methods: Serum SOST levels were quantified with a sand-
wich enzyme-linked immunosorbent assay (ELISA) preoperatively
and six months postoperatively. Anterior vertebral height, kyphotic
angles, and Visual Analogue Scale (VAS) scores were also recorded.
Results: Serum SOST was highly expressed in patients and remained
negatively correlated with bone mineral density (BMD). Vertebral
heights, local kyphotic angles, and VAS scores were all significantly
improved after PKP. However, serum SOST was positively correlated
with BMD six months after surgery. Conclusion: PKP was an effective
treatment strategy for osteoporotic thoracolumbar vertebral compres-
sion fractures, improving BMD and decreasing serum SOST levels.
Level of Evidence II, Prospective comparative study.
