Title of article :
Crystal structure of vilazodone hydrochloride methanol monosolvate
Author/Authors :
Hu, Xiu-Rong Chemistry Department - Zhejiang University, People's Republic of China , Ye, Jia-Li College of Pharmaceutical Science - Zhejiang Chinese Medical University, People's Republic of China , Gu, Jian-Ming Chemistry Department - Zhejiang University, People's Republic of China
Abstract :
In the title compound, C26H28N5O2+·Cl−·CH3OH {systematic name: 4-(2-carbamoyl-1-benzofuran-5-yl)-1-[4-(5-cyano-1H-indol-3-yl)butyl]piperazin-1-ium chloride methanol monosolvate}, the protonated piperazine ring adopts a chair conformation. The indole ring plane is nearly perpendicular to the benzofuran ring system, with a dihedral angle of 85.77 (2)°. In the crystal, the organic cations, Cl− anions and methanol solvent molecules are linked by classical N—H⋯O and N—H⋯Cl hydrogen bonds, and weak C—H⋯O and C—H⋯π interactions into a three-dimensional supramolecular architecture.
Keywords :
crystal structure , hydrogen bonds , piperazine , benzofuran , indole
Journal title :
Acta Crystallographica Section E: Crystallographic Communications
