Author/Authors :
Kim, Ji Hye Konyang University Hospital - Konyang University College of Medicine, Daejeon , Seo, Dae-Hong Chungmu Hospital, Cheonan , Ban, Ga-Young Department of Allergy and Clinical Immunology - Ajou University School of Medicine - Suwon, Korea , Yang, Eun-Mi Department of Allergy and Clinical Immunology - Ajou University School of Medicine - Suwon, Korea , Shin, Yoo Seob Department of Allergy and Clinical Immunology - Ajou University School of Medicine - Suwon, Korea , Ye, Young-Min Department of Allergy and Clinical Immunology - Ajou University School of Medicine - Suwon, Korea , Park, Hae-Sim Department of Allergy and Clinical Immunology - Ajou University School of Medicine - Suwon, Korea
Abstract :
We report a case of 20-year-old female patient with ofloxacin-induced anaphylaxis
mediated by IgG4 antibody.
One of second-generation fluoroquinolone, ofloxacin is prescribed widely to treat
bacterial infections. Reports of serious hypersensitivity reactions to quinolone are increasing due to high consumption worldwide [1].
The pathogenesis of anaphylaxis caused by ofloxacin is not yet fully understood, as
it is not commonly reported. There has been a report demonstrating high serum specific IgE levels to ofloxacin-human serum albumin (HSA) conjugate using enzymelinked immunosorbent assay (ELISA), enzyme-linked immunospecific assay [2];
however, this is the first report to suggest an IgG4-mediated but not IgE-mediated
mechanism in a patient with ofloxacin-induced anaphylaxis.
