Author/Authors :
Barros, Pedro Paulo Faculty of Pharmaceutical Sciences - Pontifícia Universidade Católica de Campinas (PUCCampinas), Brazil , Gonçalves, Gisele Mara Silva Faculty of Pharmaceutical Sciences - Pontifícia Universidade Católica de Campinas (PUCCampinas), Brazil , Silva, Gustavo Henrique da Faculty of Pharmaceutical Sciences - Pontifícia Universidade Católica de Campinas (PUCCampinas), Brazil , Bastos, Maria Clara Villaça Dias Faculty of Pharmaceutical Sciences - FAPIC (Fundo de Apoio à Iniciação Científica), PUC-Campinas, Brazil , Ramos, Loren Nogaroto Faculty of Pharmaceutical Sciences - FAPIC (Fundo de Apoio à Iniciação Científica), PUC-Campinas, Brazil , Fernandes, Marilia Marinello Faculty of Pharmaceutical Sciences - FAPIC (Fundo de Apoio à Iniciação Científica), PUC-Campinas, Brazil
Abstract :
Purpose:
To investigate the effects of capsiate treatment on hepatic hyperplasia in partially hepatectomized rats.
Methods:
The animals were divided into a Capsiate group (CPH), a Capsiate Post-Partial Hepatectomy group (CPPH) and a Partial Hepatectomy Control group (PH). CPH and CPPH animals received 60 mg/kg/day Capsiate for 30 days. Next, the rats underwent partial hepatectomy. CPPH animals continued to receive treatment for 48 h after partial hepatectomy. Liver tissue and intracardiac blood samples were obtained 24 or 48 h after PH.
Results:
Capsiate treatment interfered with hepatic parameters, reducing the number of mitoses and apoptosis and increasing blood ALT and alkaline phosphatase concentrations.
Conclusion:
Capsiate treatment preceding hepatic surgery may compromise the initial period of postoperative recovery.
Keywords :
Alanine Transaminase , Aspartate Aminotransferases , Apoptosis , Mitotic Index , Rats
