Title of article :
Rectal application of argan oil improves healing of colorectal anastomosis in rats
Author/Authors :
Barlas, Aziz Mutlu Department of General Surgery, Ankara, Turkey , Kuru, Serdar Department of General Surgery, Ankara, Turkey , Kismet, Kemal Department of General Surgery, Ankara, Turkey , Cavusoglu, Turgut Department of General Surgery, Ankara, Turkey , Bag, Yusuf Murat Department of General Surgery, Ankara, Turkey , Senes, Mehmet Department of Biochemistry, Ankara, Turkey , Cihan, Neslihan Department of Biochemistry, Ankara, Turkey , Celepli, Pinar Department of Pathology, Ankara, Turkey , Unal, Yilmaz Department of General Surgery, Ankara, Turkey , Hucumenoglu, Sema Department of Pathology, Ankara, Turkey
Pages :
12
From page :
565
To page :
576
Abstract :
Purpose: To investigate the possible effects of argan oil on the healing of colorectal anastomoses. Methods: I n Group 1 (sham), laparotomy was performed and the colon was mobilized. In the control (Group 2) and argan oil (Group 3) groups, colonic resection and anastomosis were applied. To the control and sham groups, 2 mL of 0.9% NaCl was administred rectally, and in the argan oil group, 2 mL/day argan oil was applied rectally for 7 days. Results: The mean bursting pressures of the argan oil and sham groups were significantly higher than the values in the control group. A significant difference was determined between the tissue hydroxyproline and prolidase levels of control group and other groups. Histopathologically, argan oil showed significant beneficial effects on colonic wound healing. In the argan oil and sham groups, the tissue malondialdehyde and fluorescent oxidation product levels were found to be lower and total sulfhydryl levels were higher than the control group. Conclusions: The rectally administered argan oil was observed to have significantly ameliorated wound healing parameters and exerted a significant antioxidant effect. This is the first study in the literature about the beneficial effects of argan oil on colorectal anastomoses.
Keywords :
Anastomosis , Surgical , Antioxidants , Argan , Rats
Journal title :
Acta Cirurgica Brasileira
Serial Year :
2018
Full Text URL :
Record number :
2622107
Link To Document :
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