Title of article :
Polycystic ovarian syndrome in adolescents: from diagnostic criteria to therapeutic management
Author/Authors :
Nicolaides, Nicolas C. Division of Endocrinology Metabolism and Diabetes - First Department of Pediatrics - “Aghia Sophia” Children’s Hospital - National and Kapodistrian University of Athens Medical School - Athens, Greece , Matheou, Andreas Manchester Medical School - University of Manchester, United Kingdom , Vlachou, Florentia Barts and the London School of Medicine and Dentistry - Queen Mary University of London, United Kingdom , Neocleous, Vassos Department of Molecular Genetics Function and Therapy - The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus , Skordis, Nicos Department of Molecular Genetics Function and Therapy - The Cyprus Institute of Neurology and Genetics, Nicosia, Cyprus
Abstract :
Polycystic ovarian syndrome is a common endocrinologic condition diagnosed in women of child-bearing age. It is primarily associated with androgen excess and ovarian dysfunction, which contribute to menstrual irregularity, oligo-anovulation, infertility, hirsutism and acne. It is associated with several systemic conditions, including type 2 diabetes mellitus, cardiovascular disease, obesity and neuropsychological disor-ders. The exact pathophysiology and clinical features are highly variable and, thus, there is still controversy in defining the diagnostic criteria. In this review, we outline the main diagnostic criteria, discuss the mechanisms involved in the complex pathogenesis, and present the associated clinical manifestations and therapeutic management of the syndrome in adolescents. (www.actabiomedica.it)
Keywords :
adolescents , hyperandrogenism , insulin resistance , ovarian dysfunction , polycystic ovarian syn-drome
Journal title :
Acta bio-medica : Atenei Parmensis
