Title of article
Whole genome sequencing for drug resistance determination in Mycobacterium tuberculosis
Author/Authors
Ismail, Nazir A. Centre for Tuberculosis - World Health Organization TB Supranational Reference Laboratory Network, National Institute for Communicable Diseases - National Health Laboratory Service - Johannesburg, South Africa , Omar, Shaheed V. Centre for Tuberculosis - World Health Organization TB Supranational Reference Laboratory Network, National Institute for Communicable Diseases - National Health Laboratory Service - Johannesburg, South Africa , Joseph, Lavania Centre for Tuberculosis - World Health Organization TB Supranational Reference Laboratory Network, National Institute for Communicable Diseases - National Health Laboratory Service - Johannesburg, South Africa , Said, Halima M. Centre for Tuberculosis - World Health Organization TB Supranational Reference Laboratory Network, National Institute for Communicable Diseases - National Health Laboratory Service - Johannesburg, South Africa , Ismail, Farzana Centre for Tuberculosis - World Health Organization TB Supranational Reference Laboratory Network, National Institute for Communicable Diseases - National Health Laboratory Service - Johannesburg, South Africa , Ismail, Nabila Centre for Tuberculosis - World Health Organization TB Supranational Reference Laboratory Network, National Institute for Communicable Diseases - National Health Laboratory Service - Johannesburg, South Africa , Gwala, Thabisile L. Centre for Tuberculosis - World Health Organization TB Supranational Reference Laboratory Network, National Institute for Communicable Diseases - National Health Laboratory Service - Johannesburg, South Africa
Pages
5
From page
1
To page
5
Abstract
South Africa remains challenged with a high tuberculosis burden accompanied by an increase in drug resistant cases. We assessed the use of the Illumina MiSeq, a next-generation sequencing platform for whole genome sequencing, followed by bioinformatic analysis using a commercial software package to determine resistance to selected drugs used for Mycobacterium tuberculosis treatment in our setting. Whole genome sequencing shows potential as a diagnostic platform for the detection of drug resistance in Mycobacterium tuberculosis with the provision of information for several drugs simultaneously.
Keywords
Whole genome sequencing , drug resistance determination , Mycobacterium tuberculosis
Journal title
African Journal of Laboratory Medicine
Serial Year
2019
Record number
2622428
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